Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome
Identifieur interne : 004768 ( Main/Exploration ); précédent : 004767; suivant : 004769Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome
Auteurs : Zheng Zhang [République populaire de Chine] ; Dongping Xu [République populaire de Chine] ; Yonggang Li [République populaire de Chine] ; Lei Jin [République populaire de Chine] ; Ming Shi [République populaire de Chine] ; Min Wang [République populaire de Chine] ; Xianzhi Zhou [République populaire de Chine] ; Hao Wu [République populaire de Chine] ; George F. Gao [République populaire de Chine] ; Fu-Sheng Wang [République populaire de Chine]Source :
- Clinical Immunology (Orlando, Fla.) [ 1521-6616 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN viral (génétique), ARN viral (sang), Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Carboxypeptidases (métabolisme), Cellules dendritiques (), Cellules dendritiques (enzymologie), Facteurs temps, Femelle, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Mâle, Numération formule sanguine, Peptidyl-Dipeptidase A, Ribavirine (usage thérapeutique), Sous-populations de lymphocytes T (enzymologie), Sous-populations de lymphocytes T (immunologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Séquence nucléotidique, Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- enzymologie : Cellules dendritiques, Sous-populations de lymphocytes T.
- génétique : ARN viral, Virus du SRAS.
- immunologie : Sous-populations de lymphocytes T, Syndrome respiratoire aigu sévère, Virus du SRAS.
- métabolisme : Carboxypeptidases.
- sang : ARN viral, Anticorps antiviraux.
- traitement médicamenteux : Syndrome respiratoire aigu sévère.
- usage thérapeutique : Hormones corticosurrénaliennes, Ribavirine.
- virologie : Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Cellules dendritiques, Facteurs temps, Femelle, Humains, Mâle, Numération formule sanguine, Peptidyl-Dipeptidase A, Séquence nucléotidique.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Adult, Antibodies, Viral (blood), Base Sequence, Blood Cell Count, Carboxypeptidases (metabolism), Dendritic Cells (classification), Dendritic Cells (drug effects), Dendritic Cells (enzymology), Female, Humans, Male, Middle Aged, Peptidyl-Dipeptidase A, RNA, Viral (blood), RNA, Viral (genetics), Ribavirin (therapeutic use), SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), T-Lymphocyte Subsets (enzymology), T-Lymphocyte Subsets (immunology), Time Factors.
- MESH :
- chemical , blood : Antibodies, Viral, RNA, Viral.
- chemical , genetics : RNA, Viral.
- chemical , metabolism : Carboxypeptidases.
- chemical , therapeutic use : Adrenal Cortex Hormones, Ribavirin.
- classification : Dendritic Cells.
- drug effects : Dendritic Cells.
- drug therapy : Severe Acute Respiratory Syndrome.
- enzymology : Dendritic Cells, T-Lymphocyte Subsets.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome, T-Lymphocyte Subsets.
- virology : Severe Acute Respiratory Syndrome.
- Adult, Base Sequence, Blood Cell Count, Female, Humans, Male, Middle Aged, Peptidyl-Dipeptidase A, Time Factors.
Abstract
In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5–7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.
Url:
DOI: 10.1016/j.clim.2005.04.015
PubMed: 15964242
PubMed Central: 7106242
Affiliations:
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Le document en format XML
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acute respiratory syndrome</title><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Yonggang" sort="Li, Yonggang" uniqKey="Li Y" first="Yonggang" last="Li">Yonggang Li</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shi, Ming" sort="Shi, Ming" uniqKey="Shi M" first="Ming" last="Shi">Ming Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, 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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhou, Xianzhi" sort="Zhou, Xianzhi" uniqKey="Zhou X" first="Xianzhi" last="Zhou">Xianzhi Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wu, Hao" sort="Wu, Hao" uniqKey="Wu H" first="Hao" last="Wu">Hao Wu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Beijing You'an Hospital, Capital Medical University, Beijing 100054, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing You'an Hospital, Capital Medical University, Beijing 100054</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><affiliation wicri:level="1"><nlm:aff id="aff3">Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 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xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term><term>T-Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Carboxypeptidases</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hormones corticosurrénaliennes</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Base Sequence</term><term>Blood Cell Count</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Peptidyl-Dipeptidase A</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Cellules dendritiques</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Numération formule sanguine</term><term>Peptidyl-Dipeptidase A</term><term>Séquence nucléotidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5–7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Liang, W N" uniqKey="Liang W">W.N. Liang</name></author><author><name sortKey="Mi, J" uniqKey="Mi J">J. 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MacLennan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name></noRegion><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name><name sortKey="Jin, Lei" sort="Jin, Lei" uniqKey="Jin L" first="Lei" last="Jin">Lei Jin</name><name sortKey="Li, Yonggang" sort="Li, Yonggang" uniqKey="Li Y" first="Yonggang" last="Li">Yonggang Li</name><name sortKey="Shi, Ming" sort="Shi, Ming" uniqKey="Shi M" first="Ming" last="Shi">Ming Shi</name><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name><name sortKey="Wu, Hao" sort="Wu, Hao" uniqKey="Wu H" first="Hao" last="Wu">Hao Wu</name><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><name sortKey="Zhou, Xianzhi" sort="Zhou, Xianzhi" uniqKey="Zhou X" first="Xianzhi" last="Zhou">Xianzhi Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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